An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.
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چکیده
منابع مشابه
HLA Class I and Class II Genes Distribution of the Sistanis in Iran
Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...
متن کاملTHE DISTRIBUTION OF CLASS I HLA ANTIGENS IN 1000 NORMAL INDIVIDUALS IN KHORASAN PROVINCE
In this paper, the antigen and gene frequencies of class I HLA antigens were evaluated in 1000 individuals in Khorasan province in northeast Iran, and compared with statistics of other countries. The results and a general discussion are presented.
متن کاملIncreased Risk of Hypertension in Low aged-carriers with rs2596542 Risk-allele
Background:Hypertension with its related disorders is one of the most common health problems among the Iranian population. Hypertension can be developed by chronic stress and a positive association between stress and rs2596542 has been confirmed. Methods:A Total number of 112 hypertensive patients and 97 healthy individuals were involved in the study. Total blood genomic-DNA was extracted and ...
متن کاملHLA-Cw Allele Frequency in Definite Meniere’s Disease Compared to Probable Meniere’s Disease and Healthy Controls in an Iranian Sample
Introduction Several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of Meniere’s disease. The aim of this study was determining the association between HLA-Cw Alleles in patients with definite Meniere’s disease and patients with probable Meniere’s disease and a control group. Materials and Methods: HLA-Cw genotyping was performed in 23 patients with def...
متن کاملULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.10.5094